Quick Answer
Duration: Up to 36 hours (as-needed dose)
Onset: 30-60 minutes
Peak effect: 2 hours after taking
Tadalafil Timeline
30-60 MIN
Onset
Effects begin. Tadalafil absorbs well regardless of food.
2 HOURS
Peak Effect
Maximum concentration in blood. Strongest effects.
UP TO 36 HOURS
Effective Window
Tadalafil's long half-life means it stays effective much longer than sildenafil (4-6 hours).
Why It Lasts So Long
Tadalafil has a half-life of about 17.5 hours, compared to sildenafil's 4-5 hours. This means it stays in your system much longer, giving you a wider window of effectiveness.
This is why it's called the "weekend pill" — take it Friday night, still effective Sunday morning.
Daily vs As-Needed
As-Needed (10-20mg)
Take 30+ minutes before activity. Lasts up to 36 hours per dose.
Daily (2.5-5mg)
Take every day. Maintains steady levels 24/7. No planning needed.