NAD+ and Sermorelin: Should Men Stack These with GLP-1s?

Two peptides gaining traction with men on GLP-1 medications. Here's what the evidence actually says about NAD+ and Sermorelin — and whether the stack makes sense.

June 19, 2026

As GLP-1 medications become central to men's health optimization, a natural question has emerged: what else can you add? Two compounds keep coming up in the conversation — NAD+ (nicotinamide adenine dinucleotide) and Sermorelin (a growth hormone-releasing hormone analog). Both are available through several of the same telehealth platforms that offer GLP-1 prescriptions, and both are popular in the men's longevity and performance community.

Here's what the evidence supports, what's still speculative, and when the stack actually makes practical sense.

NAD+: The Cellular Energy Molecule

What It Is

NAD+ is a coenzyme present in every cell of your body. It plays a central role in energy metabolism (converting food into cellular energy), DNA repair, and the regulation of cellular aging processes. NAD+ levels decline naturally with age — by age 50, most people have roughly half the NAD+ levels they had at 20.

The Evidence

NAD+ precursors (NMN and NR) have shown impressive results in animal models: improved mitochondrial function, extended lifespan in mice, and protection against age-related metabolic decline. In humans, the evidence is more limited. Small clinical trials show that NAD+ supplementation can raise blood NAD+ levels, but whether this translates to the dramatic health benefits seen in animal models is still being studied.

What we know from human data: NAD+ supplementation appears safe at standard doses, can improve markers of cellular energy metabolism, and may support DNA repair processes. What we don't yet know with certainty is whether raising NAD+ levels in humans produces the longevity benefits seen in mice.

Why Men on GLP-1s Consider It

When you're in a caloric deficit (as GLP-1 medications induce), your cells are working harder with fewer energy inputs. NAD+ supplementation may support mitochondrial efficiency during this metabolically demanding period — essentially giving your cells better tools to work with during caloric restriction. This is plausible but not yet proven in clinical trials specific to GLP-1 users.

Sermorelin: The Growth Hormone Secretagogue

What It Is

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH). Rather than injecting growth hormone directly (which carries significant side effects and is tightly regulated), Sermorelin stimulates your pituitary gland to produce more of its own growth hormone through your body's natural feedback mechanisms.

The Evidence

Sermorelin is FDA-approved for diagnosing and treating growth hormone deficiency in children, with a well-established safety profile. In adults, it's used off-label for anti-aging, body composition improvement, and recovery enhancement. Clinical data in adults shows that Sermorelin can increase growth hormone secretion, improve body composition (more lean mass, less fat mass), enhance recovery from exercise, and improve sleep quality (growth hormone is primarily released during deep sleep).

Why Men on GLP-1s Consider It

This is where the stack logic gets compelling. GLP-1 medications cause weight loss that includes 20–40% lean tissue — muscle, bone mineral density, and metabolically active mass. Growth hormone is one of the body's primary signals for maintaining lean tissue. By stimulating natural growth hormone production with Sermorelin, men on GLP-1s may be able to shift the weight loss ratio toward more fat loss and less muscle loss.

Additionally, growth hormone enhances recovery from resistance training — and as ENDO 2026 data showed, GLP-1 users need to be particularly intentional about exercise to prevent the activity decline that leads to accelerated muscle loss.

The Stack: When It Makes Sense

Combining a GLP-1 medication with NAD+ and/or Sermorelin makes the most practical sense for men who are actively doing resistance training and want to maximize muscle preservation during weight loss, men over 40 who are experiencing age-related declines in both growth hormone and NAD+ levels, and men who can afford the additional cost and are already optimizing protein intake, sleep, and training.

It makes less sense for men who haven't yet dialed in the fundamentals (protein, training, sleep), men on tight budgets (the GLP-1 alone delivers the biggest bang for buck), or men who aren't in a consistent exercise routine (Sermorelin's lean mass benefits require resistance training stimulus to be meaningful).

Where to Get the Stack